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Selective Targeting of the KRAS G12C Mutant: Kicking KRAS When It's Down

Hobbs, G. Aaron; Wittinghofer, Alfred; Der, Channing J.

Cancer cell. Volume 29:Issue 3 (2016); pp 251-253

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  • Title:
    Selective Targeting of the KRAS G12C Mutant: Kicking KRAS When It's Down
  • Author: Hobbs, G. Aaron;
    Wittinghofer, Alfred;
    Der, Channing J.
  • Found In: Cancer cell. Volume 29:Issue 3 (2016); pp 251-253
  • Journal Title: Cancer cell
  • Subjects: Dewey: 611.0181
  • Rights: Licensed
  • Abstract: Two recent studies evaluated a small molecule that specifically binds to and inactivates the KRAS G12C mutant. The new findings argue that the perception that mutant KRAS is persistently frozen in its active GTP-bound form may not be accurate. Two recent studies evaluated a small molecule that specifically binds to and inactivates the KRAS G12C mutant. The new findings argue that the perception that mutant KRAS is persistently frozen in its active GTP-bound form may not be accurate.
  • Identifier: System Number: ETOCvdc_100064176471.0x000001; Journal ISSN: 1535-6108; 10.1016/j.ccell.2016.02.015
  • Publication Date: 2016
  • Physical Description: Electronic
  • Shelfmark(s): 3046.464170
  • UIN: ETOCvdc_100064176471.0x000001

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