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Metabolic reprograming of anti-tumor immunity

Sukumar, Madhusudhanan; Kishton, Rigel J; Restifo, Nicholas P

Current opinion in immunology. Volume 46: (2017, June); pp 14-22 -- Elsevier

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  • Title:
    Metabolic reprograming of anti-tumor immunity
  • Author: Sukumar, Madhusudhanan;
    Kishton, Rigel J;
    Restifo, Nicholas P
  • Found In: Current opinion in immunology. Volume 46: (2017, June); pp 14-22
  • Journal Title: Current opinion in immunology
  • Subjects: Allergy--Abstracts--Periodicals; Allergy--Periodicals; Immunology--Abstracts--Periodicals; Immunology--Periodicals; Dewey: 616.079
  • Rights: Licensed
  • Publication Details: Elsevier
  • Abstract: Highlights Memory T cells have quiescent metabolism. Activation of T cells triggers both glycolysis and oxidative phosphorylation. Elevated T cell metabolic activity is necessary at the tumor site to promote tumor killing. High mitochondrial membrane potential (ΔΨm) is associated with cytokine production and capacity for cytotoxic function. Metabolic reprogramming of T cells may improve TCR and chimeric antigen receptor (CAR) based immunotherapy. Immunotherapies designed to trigger T cell destruction of tumor cells can result in sustained and complete responses in patients whose cancers were resistant to available treatment options. Evidence suggests that powering the T cell response – how T cells generate energy – plays an important role in their effectiveness. Furthermore the metabolism of T cells can be modulated to improve their anti-cancer activities. In this review, we will discuss the key metabolic properties of anti-cancer T cells, along with potential strategies to enhance immunotherapy through the modulation of T cell metabolism.
  • Identifier: System Number: ETOCvdc_100063263689.0x000001; Journal ISSN: 0952-7915; 10.1016/j.coi.2017.03.011
  • Publication Date: 2017
  • Physical Description: Electronic
  • Shelfmark(s): 3500.775300
  • UIN: ETOCvdc_100063263689.0x000001

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