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Trace elements levels in centenarian 'dodgers'

Alis, Rafael et al.

Journal of trace elements in medicine and biology. Volume 35 (2016); pp 103-106 -- Elsevier Science

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  • Title:
    Trace elements levels in centenarian 'dodgers'
  • Author: Alis, Rafael;
    Santos-Lozano, Alejandro;
    Sanchis-Gomar, Fabian;
    Pareja-Galeano, Helios;
    Fiuza-Luces, Carmen;
    Garatachea, Nuria;
    Lucia, Alejandro;
    Emanuele, Enzo
  • Found In: Journal of trace elements in medicine and biology. Volume 35 (2016); pp 103-106
  • Journal Title: Journal of trace elements in medicine and biology
  • Subjects: Oligoéléments dans l'organisme--Périodiques; Trace elements in the body--Periodicals; Aging--Selenium--Copper--Lifespan; Dewey: 612.01524
  • Rights: Licensed
  • Publication Details: Elsevier Science
  • Abstract: Abstract Trace element bioavailability can play a role in several metabolic and physiological pathways known to be altered during the aging process. We aimed to explore the association of trace elements with increased lifespan by analyzing the circulating levels of seven trace elements (Cr, Cu, Fe, Mn, Mo, Se and Zn) in a cohort of healthy centenarians or 'dodgers' (≥100 years, free of major age-related diseases) in comparison with sex-matched younger elderly controls. Centenarians showed significant lower Cu (783.7 (76.7, 1608.9) vs 962.5 (676.3, 2064.4) μg/mL, P < 0.001), but higher Fe (1.3 (0.4, 4.7) vs 1.1 (0.5, 8.4) μg/mL, P = 0.003) and Se (85.7 (43.0, 256.7) vs 77.8 (24.3, 143.8) ng/mL, P = 0.002) values compared with elderly controls. The logistic regression analysis identified the combination of Cu and Se as significant predictor variables associated with successful aging ( P = 0.001), while receiver operating characteristic (ROC) analysis confirmed that Cu and Se (either alone or in combination) were independent variables associated with healthy aging. An 'improved' trace element profile (reduced Cu and elevated Se, which are involved in key physiological processes) could play a role in the resistance to disease showed by centenarian 'dodgers', and, therefore, at least partly, be involved in the healthy aging phenotype shown by these subjects. These results should be confirmed in larger cohorts of other geographic/ethnic origin and the potential cause–effect association tested in mechanistic experimental settings.
  • Identifier: System Number: ETOCvdc_100060122309.0x000001; Journal ISSN: 0946-672X; doi/10.1016/j.jtemb.2016.02.002
  • Publication Date: 2016
  • Physical Description: Electronic
  • Shelfmark(s): 5069.744400
  • UIN: ETOCvdc_100060122309.0x000001

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