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Mechanisms of Targeted Therapy Resistance Take a De-TOR

Gentry, Leanna R.; Martin, Timothy D.; Der, Channing J.

Cancer cell. Volume 24:Issue 3 (2013); pp 284-286

Online access

  • Title:
    Mechanisms of Targeted Therapy Resistance Take a De-TOR
  • Author: Gentry, Leanna R.;
    Martin, Timothy D.;
    Der, Channing J.
  • Found In: Cancer cell. Volume 24:Issue 3 (2013); pp 284-286
  • Journal Title: Cancer cell
  • Subjects: Dewey: 611.0181
  • Rights: Licensed
  • Abstract: The effectiveness of cancer therapeutics targeting signal transduction pathways is comprised of a diversity of mechanisms that drive de novo or acquired resistance. Two recent studies identify mTOR activation as a point of convergence of mechanisms that cause resistance to inhibitors of the Raf-MEK-ERK and PI3K signaling.
  • Identifier: System Number: ETOCvdc_100058276720.0x000001; Journal ISSN: 1535-6108; doi/10.1016/j.ccr.2013.08.021
  • Publication Date: 2013
  • Physical Description: Electronic
  • Shelfmark(s): 3046.464170
  • UIN: ETOCvdc_100058276720.0x000001

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