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Membrane Protein Dislocation by the Rhomboid Pseudoprotease Dfm1: No Pore Needed?

Avci, Dönem; Lemberg, Marius K.

Molecular cell. Volume 69:Number 2 (2018, January 18th); pp 161-162

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  • Title:
    Membrane Protein Dislocation by the Rhomboid Pseudoprotease Dfm1: No Pore Needed?
  • Author: Avci, Dönem;
    Lemberg, Marius K.
  • Found In: Molecular cell. Volume 69:Number 2 (2018, January 18th); pp 161-162
  • Journal Title: Molecular cell
  • Subjects: Dewey: 572.805
  • Rights: Licensed
  • Abstract: Defective ER-resident membrane proteins need to be ejected into the cytoplasm in order to be degraded by the proteasome, but the exact mechanism remains unclear. In this issue of Molecular Cell, Neal et al. (2018)reveal that the rhomboid pseudoprotease Dfm1 defines the central ERAD component for membrane protein dislocation. Defective ER-resident membrane proteins need to be ejected into the cytoplasm in order to be degraded by the proteasome, but the exact mechanism remains unclear. In this issue of Molecular Cell, Neal et al. (2018) reveal that the rhomboid pseudoprotease Dfm1 defines the central ERAD component for membrane protein dislocation.
  • Identifier: System Number: ETOCvdc_100055521150.0x000001; Journal ISSN: 1097-2765; 10.1016/j.molcel.2017.12.031
  • Publication Date: 2018
  • Physical Description: Electronic
  • Shelfmark(s): 5900.802750
  • UIN: ETOCvdc_100055521150.0x000001

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