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Cardiovascular risk in different obesity phenotypes over a decade follow-up: Tehran Lipid and Glucose Study

Mirzaei, Bita et al.

Atherosclerosis. Volume 258 (2017); pp 65-71 -- Elsevier Ireland Ltd

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  • Title:
    Cardiovascular risk in different obesity phenotypes over a decade follow-up: Tehran Lipid and Glucose Study
  • Author: Mirzaei, Bita;
    Abdi, Hengameh;
    Serahati, Sara;
    Barzin, Maryam;
    Niroomand, Mahtab;
    Azizi, Fereidoun;
    Hosseinpanah, Farhad
  • Found In: Atherosclerosis. Volume 258 (2017); pp 65-71
  • Journal Title: Atherosclerosis
  • Subjects: Arteriosclerosis--Periodicals; Electronic journals; Dewey: 616.136
  • Rights: Licensed
  • Publication Details: Elsevier Ireland Ltd
  • Abstract: Abstract Background and aims Considering the inconsistent data available on cardiovascular (CV) risk of different obesity phenotypes, the aim of this study was to investigate the development of cardiovascular disease (CVD) in different obesity phenotypes over a median follow-up of 12 years. Methods In this large population-based cohort, 7842 participants (44.8% men), aged ≥ 30 years, were enrolled. Participants were divided into six phenotypes based on body mass index and metabolic status. Metabolic health was defined based on two definitions: 1) having ≤1 component of metabolic syndrome using the Joint Interim Statement (JIS) criteria and 2) homeostasis model assessment-insulin resistance (HOMA-IR) < 2.6 mole × μU/L 2 . Multivariate adjusted hazard ratios (HRs) were calculated for cardiovascular events. Results A total of 712 new CVD events occurred. CV risk increased in all metabolically unhealthy phenotypes. Multivariable adjusted HRs for CVD events in metabolically healthy overweight (MHOW) and metabolically healthy obese (MHO) participants were 1.22 (0.73–2.04) and 1.74 (0.68–4.44), respectively. CV risk increased in all obesity phenotypes based on insulin resistance except the insulin resistance-normal weight group. However, this increased risk disappeared after further adjustment for metabolic risk factors. Conclusions Our findings showed that CV risk did not increase in MHOW and MHO phenotypes over a 12-year follow-up. However, all metabolically unhealthy phenotypes were associated with increased incident CVD. Further studies with longer follow-up are needed to confirm the benign nature of MHOW/MHO phenotypes. Highlights Data regarding cardiovascular risk of different obesity phenotypes is inconsistent. 7842 individuals, aged ≥30 years, were investigated over 12 years of follow-up. Cardiovascular risk increased in all metabolically unhealthy phenotypes. Cardiovascular risk did not increase in metabolically healthy overweight (MHOW) and obese (MHO) individuals. Further studies with longer follow-up are needed to confirm the benign nature of MHOW/MHO phenotypes.
  • Identifier: System Number: ETOCvdc_100054407424.0x000001; Journal ISSN: 0021-9150; doi/10.1016/j.atherosclerosis.2017.02.002
  • Publication Date: 2017
  • Physical Description: Electronic
  • Shelfmark(s): 1765.874000
  • UIN: ETOCvdc_100054407424.0x000001

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