skip to main content
Show Results with:

49. Plexiform angiomyxoid myofibroblastic tumour

Tan, Christopher Y.; Santos, Leonardo D.

Elsevier B.V. Issue:; -- 2011

Online access

  • Title:
    49. Plexiform angiomyxoid myofibroblastic tumour
  • Author: Tan, Christopher Y.;
    Santos, Leonardo D.
  • Found In: . ; ; -
  • Rights: Licensed
  • Publication Details: Elsevier B.V.
  • Abstract: Plexiform angiomyxoid myofibroblastic tumour (PAMT) is a recently described rare gastric mesenchymal tumour. We are aware of only seven reported cases. We report an additional PAMT case in a 34-year-old Filipino man who presented with abdominal mass and decreased appetite. The imaging showed a distal gastric mass. Grossly, there was a 35mm ulcerated tan, polypoid myxoid mass. It continued into a 245mm haemorrhagic, perforated sac-like structure.Histologically, the plexiform tumour with <2% proliferation index (Ki-67) was composed of bland spindle cells without necrosis, significant atypia or mitoses. Abundant myxoid stroma (+ Alcian blue and colloidal iron; – PAS) separated the neo-plastic cells (+ SMA and desmin; – c-kit, MNF, S-100 and CD34).KIT(exons 9, 11, 13 and 17) andPDGFRA(exon 16) genes showed no mutation. On electron microscopy (EM), the spindle cells were widely spaced in myxoid stroma composed of Type 1 collagen. The cells showed dilated ER and cytoplasmic and filament bundles with dendrites, consistent with myofibroblastic origin. The differential diagnosis of PAMT includes GIST, leiomyoma, peripheral nerve sheath tumour and solitary fibrous tumour. Immunohistochemistry, EM andKITandPDGFRAgenetic studies are essential, especially in differentiating GIST from PAMT, because of a major implication on the treatment. The current case shared the clinical, histological, immunophenotypical and EM features of the previously described PAMT cases. On follow up, our patient is alive and well without tumour recurrence.
  • Publication Date: 2011
  • Physical Description: Electronic
  • UIN: ETOCvdc_100054070606.0x000001

Searching Remote Databases, Please Wait