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BiP links TOR signaling to ER stress in Chlamydomonas

Crespo, José L.

Plant signaling & behavior. Volume 7:Number 2 (2012, February 1st); pp 273-275 -- Taylor & Francis

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  • Title:
    BiP links TOR signaling to ER stress in Chlamydomonas
  • Author: Crespo, José L.
  • Found In: Plant signaling & behavior. Volume 7:Number 2 (2012, February 1st); pp 273-275
  • Journal Title: Plant signaling & behavior
  • Subjects: Electronic journals; Plant cellular signal transduction--Periodicals; Plant ecophysiology--Periodicals; Periodicals; Plant cellular signal transduction; Plant ecophysiology; BiP chaperone--Chlamydomonas--endoplasmic reticulum stress--phosphorylation/dephosphorylation--protein synthesis--TOR kinase; Dewey: 581
  • Rights: Licensed
  • Publication Details: Taylor & Francis
  • Abstract:

    The highly conserved target of rapamycin (TOR) Ser/Thr kinase promotes protein synthesis under favorable growth conditions in all eukaryotes. Downregulation of TOR signaling in the model unicellular green alga Chlamydomonas reinhardtii has recently revealed a link between control of protein synthesis, endoplasmic reticulum (ER) stress and the reversible modification of the BiP chaperone by phosphorylation. Inhibition of protein synthesis by rapamycin or cycloheximide resulted in the phosphorylation of BiP on threonine residues while ER stress induced by tunicamycin or heat shock caused the fast dephosphorylation of the protein. Regulation of BiP function by phosphorylation/dephosphorylation events was proposed in early studies in mammalian cells although no connection to TOR signaling has been established so far. Here I will discuss about the coordinated regulation of BiP modification by TOR and ER stress signals in Chlamydomonas.


  • Identifier: System Number: ETOCvdc_100050686591.0x000001; Journal ISSN: 1559-2316; 10.4161/psb.18767
  • Publication Date: 2012
  • Physical Description: Electronic
  • UIN: ETOCvdc_100050686591.0x000001

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