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Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy

Kishton, Rigel J.; Sukumar, Madhusudhanan; Restifo, Nicholas P.

Cell metabolism. Volume 26:Issue 1 (2017); pp 94-109 -- Cell Press

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  • Title:
    Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy
  • Author: Kishton, Rigel J.;
    Sukumar, Madhusudhanan;
    Restifo, Nicholas P.
  • Found In: Cell metabolism. Volume 26:Issue 1 (2017); pp 94-109
  • Journal Title: Cell metabolism
  • Subjects: Cell metabolism--Periodicals; Metabolism--Disorders--Periodicals; immunotherapy--cancer--T cell metabolism--epigenetics--longevity--checkpoint inhibitor--differentiation--tumor--aging--memory; Dewey: 572.4
  • Rights: Licensed
  • Publication Details: Cell Press
  • Abstract: Cancer immunotherapy is an increasingly successful strategy for the treatment of patients who have advanced or conventional therapy-resistant cancers. T cells are key mediators of tumor destruction and their specificity for tumor-expressed antigens is of paramount importance, but other T cell-intrinsic qualities, such as durability, longevity, and functionality also play important roles in determining the efficacy of immunotherapy. The cellular energetic pathways that are utilized by T cells play a key role in regulating each of these qualities. Metabolic activity, which both regulates and is regulated by cellular signaling pathways and epigenetics, also profoundly influences the trajectories of T cell differentiation and fate. In this Review, we discuss how cell metabolism influences T cell anti-tumor activity, the metabolic qualities of highly-functional T cells, and strategies to modulate metabolism for improving the immune response to tumors. Does metabolism determine the fate of T cells? Kishton et al. review the relationships between metabolism, aging, and epigenetics in T cells, which are at the heart of new cancer immunotherapies. By manipulating key metabolic pathways, the efficacy of T cells can be improved in the setting of cancer immunotherapy.
  • Identifier: System Number: ETOCvdc_100049715563.0x000001; Journal ISSN: 1550-4131; doi/10.1016/j.cmet.2017.06.016
  • Publication Date: 2017
  • Physical Description: Electronic
  • Shelfmark(s): 3097.810000
  • UIN: ETOCvdc_100049715563.0x000001

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