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Characterization of Cardiac Tumors in Children by Cardiovascular Magnetic Resonance Imaging

Beroukhim, Rebecca S. et al.

Journal of the American College of Cardiology. Volume 58:Number 10 (2011); pp 1044-1054 -- Elsevier Science

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  • Title:
    Characterization of Cardiac Tumors in Children by Cardiovascular Magnetic Resonance Imaging
  • Author: Beroukhim, Rebecca S.;
    Prakash, Ashwin;
    Valsangiacomo Buechel, Emanuela R.;
    Cava, Joseph R.;
    Dorfman, Adam L.;
    Festa, Pierluigi;
    Hlavacek, Anthony M.;
    Johnson, Tiffanie R.;
    Keller, Marc S.;
    Krishnamurthy, Rajesh;
    Misra, Nilanjana;
    Moniotte, Stephane;
    Parks, W. James;
    Powell, Andrew J.;
    Soriano, Brian D.;
    Srichai, Monvadi B.;
    Yoo, Shi-Joon;
    Zhou, Jing;
    Geva, Tal
  • Found In: Journal of the American College of Cardiology. Volume 58:Number 10 (2011); pp 1044-1054
  • Journal Title: Journal of the American College of Cardiology
  • Subjects: Cardiology--Periodicals; Cardiology--Research; Medicine--Periodicals; ECG--FPP--MDE--MRI--SSFP--T1-TSE--T2-TSE--TE--TR--TSE; cardiac tumor--diagnosis--magnetic resonance imaging--pediatrics; Dewey: 616.12
  • Rights: Licensed
  • Publication Details: Elsevier Science
  • Abstract: Objectives The aim of this study was to report the results of an international multicenter experience of cardiac magnetic resonance imaging (MRI) evaluation of cardiac tumors in children, each with histology correlation or a diagnosis of tuberous sclerosis, and to determine which characteristics are predictive of tumor type. Background Individual centers have relatively little experience with diagnostic imaging of cardiac tumors in children, because of their low prevalence. The accuracy of cardiac MRI diagnosis on the basis of a pre-defined set of criteria has not been tested. Methods An international group of pediatric cardiac imaging centers was solicited for case contribution. Inclusion criteria comprised: 1) age at diagnosis ≤18 years; 2) cardiac MRI evaluation of cardiac tumor; and 3) histologic diagnosis or diagnosis of tuberous sclerosis. Data from the cardiac MRI images were analyzed for mass characteristics. On the basis of pre-defined cardiac MRI criteria derived from published data, 3 blinded investigators determined tumor type, and their consensus diagnoses were compared with histologic diagnoses. Results Cases (n = 78) submitted from 15 centers in 4 countries had the following diagnoses: fibroma (n = 30), rhabdomyoma (n = 14), malignant tumor (n = 12), hemangioma (n = 9), thrombus (n = 4), myxoma (n = 3), teratoma (n = 2), and paraganglioma, pericardial cyst, Purkinje cell tumor, and papillary fibroelastoma (n = 1, each). Reviewers who were blinded to the histologic diagnoses correctly diagnosed 97% of the cases but included a differential diagnosis in 42%. Better image quality grade and more complete examination were associated with higher diagnostic accuracy. Conclusions Cardiac MRI can predict the likely tumor type in the majority of children with a cardiac mass. A comprehensive imaging protocol is essential for accurate diagnosis. However, histologic diagnosis remains the gold standard, and in some cases malignancy cannot be definitively excluded on the basis of cardiac MRI images alone.
  • Identifier: System Number: ETOCvdc_100049291560.0x000001; Journal ISSN: 0735-1097; doi/10.1016/j.jacc.2011.05.027
  • Publication Date: 2011
  • Physical Description: Electronic
  • Shelfmark(s): 4685.500000
  • UIN: ETOCvdc_100049291560.0x000001

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