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Hsp83 loss suppresses proteasomal activity resulting in an upregulation of caspase-dependent compensatory autophagy

Choutka, Courtney et al.

Autophagy -- Taylor & Francis -- Volume: 13 9; (pages 1573-1589) -- 2017

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  • Title:
    Hsp83 loss suppresses proteasomal activity resulting in an upregulation of caspase-dependent compensatory autophagy
  • Author: Choutka, Courtney;
    DeVorkin, Lindsay;
    Go, Nancy Erro;
    Hou, Ying-Chen Claire;
    Moradian, Annie;
    Morin, Gregg B.;
    Gorski, Sharon M.
  • Found In: Autophagy. Volume 13:Issue 9(2017); 201709; 1573-1589
  • Journal Title: Autophagy
  • Subjects: Autophagic vacuoles; Apoptosis; Cell death; Lysosomes; Degeneration (Pathology); Autophagy; Cell Death; Lysosomes; LCSH: Autophagic vacuoles; LCSH: Apoptosis; LCSH: Cell death; LCSH: Lysosomes; LCSH: Degeneration (Pathology); Dewey: 571.936
  • Rights: Licensed
  • Publication Details: Taylor & Francis
  • Abstract: ABSTRACT

    The 2 main degradative pathways that contribute to proteostasis are the ubiquitin-proteasome system and autophagy but how they are molecularly coordinated is not well understood. Here, we demonstrate an essential role for an effector caspase in the activation of compensatory autophagy when proteasomal activity is compromised. Functional loss of Hsp83, theDrosophilaortholog of human HSP90 (heat shock protein 90), resulted in reduced proteasomal activity and elevated levels of the effector caspase Dcp-1. Surprisingly, genetic analyses showed that the caspase was not required for cell death in this context, but instead was essential for the ensuing compensatory autophagy, female fertility, and organism viability. The zymogen pro-Dcp-1 was found to interact with Hsp83 and undergo proteasomal regulation in an Hsp83-dependent manner. Our work not only reveals unappreciated roles for Hsp83 in proteasomal activity and regulation of Dcp-1, but identifies an effector caspase as a key regulatory factor for sustaining adaptation to cell stress in vivo.


  • Identifier: Journal ISSN: 1554-8627
  • Publication Date: 2017
  • Physical Description: Electronic
  • Shelfmark(s): 1835.065800
    ELD Digital store
  • UIN: ETOCvdc_100049111673.0x000001

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