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Cannabis as Secondary Drug Is Not Associated With a Greater Risk of Death in Patients With Opiate, Cocaine, or Alcohol Dependence

Fuster, Daniel et al.

Journal of addiction medicine -- Lippincott Williams & Wilkins -- Volume: 11 1; (pages 34-39) -- 2017

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  • Title:
    Cannabis as Secondary Drug Is Not Associated With a Greater Risk of Death in Patients With Opiate, Cocaine, or Alcohol Dependence
  • Author: Fuster, Daniel;
    Sanvisens, Arantza;
    Bolao, Ferran;
    Zuluaga, Paola;
    Rivas, Inmaculada;
    Farré, Magi;
    Tor, Jordi;
    Muga, Robert
  • Found In: Journal of addiction medicine. Volume 11:Number 1(2017); 2017; 34-39
  • Journal Title: Journal of addiction medicine
  • Subjects: Substance abuse; Substance abuse Treatment; Substance-Related Disorders; LCSH: Substance abuse; LCSH: Substance abuse Treatment; Dewey: 616.86005
  • Rights: Licensed
  • Publication Details: Lippincott Williams & Wilkins
  • Abstract: Background:

    The health burden of cannabis use in patients with other substance dependencies is not fully understood.

    Objective:

    To assess the impact of cannabis use as secondary drug on mortality of patients with other major substance use disorders.

    Participants:

    Patients with opiate, cocaine, or alcohol dependence admitted to detoxification from 2001 to 2010 at a teaching hospital in Badalona, Spain.

    Main Measurements:

    Sociodemographic characteristics, drug use, medical comorbidities, and urine drug screens were obtained at admission. Deaths were ascertained through clinical records and a death registry. Mortality rates and Cox regression models were used to analyze the association between urinary cannabis and mortality.

    Results:

    A total of 474 patients (20% women) were admitted with a median age of 38 years (interquartile range: 32–44 years). The main substances that motivated admissions were opiates (27%), cocaine (24%), and alcohol (49%). Positive urinary cannabis was detected in 168 patients (35%). Prevalence of cannabis use among patients with opiate, cocaine, or alcohol dependence was 46.5%, 42.9%, and 25.5%, respectively. At admission, 110 (23.7%) patients had human immunodeficiency virus infection and 217 (46.5%) had hepatitis C virus infection. Patients were studied for a median of 5.6 years (interquartile range: 2.6–7.7 years) (2454.7 person-years), and at the end of the study, 50 patients (10.5%) had died, yielding a mortality rate of 2.04 × 100 patient-years (95% confidence interval: 1.53–2.66). There was no association between cannabis detection and overall mortality in the adjusted regression models [hazard ratio (95% confidence interval): 1.12 (0.60–2.00),P = 0.73], but acquired immune deficiency syndrome-related deaths were more frequent in those positive for cannabis (26% vs 2%,P = 0.03).

    Conclusion:

    Positive urinary cannabis did not confer an increased risk of death in patients with severe opiate, cocaine or alcohol dependence.


  • Identifier: Journal ISSN: 1932-0620
  • Publication Date: 2017
  • Physical Description: Electronic
  • Shelfmark(s): ELD Digital store
  • UIN: ETOCvdc_100042292028.0x000001

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