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The effects of a thermophile metabolite, tryptophol, upon protecting shrimp against white spot syndrome virus

Zhu, Fei; Jin, Min

Fish & shellfish immunology -- Elsevier Science -- Volume: 47 2; (pages 777-781) -- 2015

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  • Title:
    The effects of a thermophile metabolite, tryptophol, upon protecting shrimp against white spot syndrome virus
  • Author: Zhu, Fei;
    Jin, Min
  • Found In: Fish & shellfish immunology. Volume 47:Number 2(2015); 201512; 777-781
  • Journal Title: Fish & shellfish immunology
  • Subjects: Fishes Immunology; Shellfish Immunology; Poissons Immunologie; Crustacés Immunologie; LCSH: Fishes Immunology; LCSH: Shellfish Immunology; Dewey: 571.9617
  • Rights: Licensed
  • Publication Details: Elsevier Science
  • Abstract: AbstractWhite spot syndrome virus (WSSV) is a shrimp pathogen responsible for significant economic loss in commercial shrimp farms and until now, there has been no effective approach to control this disease. In this study, tryptophol (indole-3-ethanol) was identified as a metabolite involved in bacteriophage–thermophile interactions. The dietary addition of tryptophol reduced the mortality in shrimpMarsupenaeus japonicuswhen orally challenged with WSSV. Our results revealed that 50 mg/kg tryptophol has a better protective effect in shrimp than 10 or 100 mg/kg tryptophol. WSSV copies in shrimp were reduced significantly (P < 0.01) when supplemented with 50 mg/kg tryptophol, indicating that virus replication was inhibited by tryptophol. Consequently, tryptophol represents an effective antiviral dietary supplement for shrimp, and thus holds significant promise as a novel and efficient therapeutic approach to control WSSV in shrimp aquaculture.Graphical abstractInhibition of WSSV replication in shrimp by dietary supplementation of 50 mg/kg tryptophol. WSSV copies in shrimp were reduced significantly (P < 0.01) when supplemented with 50 mg/kg tryptophol, indicating that virus replication was inhibited by tryptophol.HighlightsThe tryptophol was identified as a metabolite which was involved in bacteriophage–thermophile interactions.The dietary addition of tryptophol reduced the mortality of shrimp.The WSSV copies in shrimp were significantly decreased when supplemented with the tryptophol.
  • Identifier: Journal ISSN: 1050-4648
  • Publication Date: 2015
  • Physical Description: Electronic
  • Shelfmark(s): ELD Digital store
    3934.880000
  • UIN: ETOCvdc_100038856990.0x000001

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