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Association Between the Plasma Levels of Mediators of Inflammation With Pain and Disability in the Elderly With Acute Low Back Pain: Data From the Back Complaints in the Elders (BACE)-Brazil Study

de Queiroz, Bárbara Zille et al.

Spine. Volume 41:Issue 3 (2016, February 1st); pp 197-203 -- Lippincott, Williams & Wilkins

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  • Title:
    Association Between the Plasma Levels of Mediators of Inflammation With Pain and Disability in the Elderly With Acute Low Back Pain: Data From the Back Complaints in the Elders (BACE)-Brazil Study
  • Author: de Queiroz, Bárbara Zille;
    Pereira, Daniele Sirineu;
    Lopes, Renata Antunes;
    Felício, Diogo Carvalho;
    Silva, Juscelio Pereira;
    de Britto Rosa, Nayza Maciel;
    Dias, João Marcos Domingues;
    Dias, Rosângela Correa;
    Lustosa, Lygia Paccini;
    Pereira, Leani Souza Máximo
  • Found In: Spine. Volume 41:Issue 3 (2016, February 1st); pp 197-203
  • Journal Title: Spine
  • Subjects: Spine--Abnormalities--Periodicals; Spine--Diseases--Periodicals; Spine--Surgery--Periodicals; back complaints in the elders--cytokines--disability--elderly--IL-1β--IL-6--inflammation--low back pain--sTNF-R1--TNF-α; Dewey: 616.73005
  • Rights: Licensed
  • Publication Details: Lippincott, Williams & Wilkins
  • Abstract: Study Design:

    Cross-sectional study with subsample of elderly women with acute low back pain (LBP), from Back Complaints in the Elders-Brazil (BACE-Brazil)

    Objective:

    To investigate the association between plasma levels of mediators of inflammation (interleukin-1 beta (IL-1β), IL-6, tumor necrosis factor alpha (TNF-α), and soluble TNF receptor 1 (sTNF-R1)) with pain and disability experienced by elderly women with acute LBP.

    Summary of Background Data:

    Among the elderly, LBP is a complaint of great importance and can lead to disability. Inflammatory cytokines are elevated in painful conditions, and may promote pain.

    Methods:

    We included 155 community-dwelling elderly women (age ≥ 65 yr), who presented with a new (acute) episode of LBP. Enzyme-linked immunosorbent assays were used to measure TNF-α, sTNF-R1, IL-1β, and IL-6. Disability was assessed using the Roland Morris Disability Questionnaire; pain was assessed using the McGill Pain Questionnaire. Linear regression models were fit with each pain and disability outcome as dependent variables: Present Pain Intensity; Qualities of pain; Severity of pain in the last week; LBP frequency and disability.

    Results:

    Depressive symptoms and IL-6 were associated and explained 20.9% of "qualities of pain" variability. TNF-α, sTNFR1, education, body mass index, and depressive symptoms explained 8.4% of "Severity of pain in the past week" variability. TNF-α, education, BMI, depressive symptoms, present pain intensity, qualities of pain, and LBP frequency explained 48.6% of "disability." No associations between inflammatory cytokines and "present pain intensity" and "LBP frequency" were found.

    Conclusion:

    Our results demonstrate associations between inflammatory markers (TNF-α and sTNFR1) and pain severity, IL-6 was associated with the qualities of pain, and TNF-α was also associated with disability. These inflammatory mediators represent new markers to be considered in the assessment and treatment of elderly patients with LBP.

    Level of Evidence:5


  • Identifier: System Number: ETOCvdc_100037153127.0x000001; Journal ISSN: 0362-2436; doi/10.1097/BRS.0000000000001214
  • Publication Date: 2016
  • Physical Description: Electronic
  • Shelfmark(s): 8413.903000
  • UIN: ETOCvdc_100037153127.0x000001

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