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Hierarchical heterogeneity in mammary tumors and its regulation by autophagy

Yeo, Syn Kok; Guan, Jun-Lin

Autophagy. Volume 12:Issue 10 (2016, October); pp 1960-1961 -- Taylor & Francis

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  • Title:
    Hierarchical heterogeneity in mammary tumors and its regulation by autophagy
  • Author: Yeo, Syn Kok;
    Guan, Jun-Lin
  • Found In: Autophagy. Volume 12:Issue 10 (2016, October); pp 1960-1961
  • Journal Title: Autophagy
  • Subjects: Autophagy--Periodicals; Cell Death--Periodicals; Apoptosis--Periodicals; Autophagic vacuoles--Periodicals; Cell death--Periodicals; Degeneration (Pathology)--Periodicals; Lysosomes--Periodicals; Periodicals; autophagy--breast cancer--cancer stem cell--epigenetic--heterogeneity; Dewey: 571.936
  • Rights: Licensed
  • Publication Details: Taylor & Francis
  • Abstract: ABSTRACT:

    Intra-tumor heterogeneity can be attributed in part to the ability of tumor cells to acquire traits associated with less differentiated cells. In MMTV-PyMT mammary tumors, this hierarchical heterogeneity can be illustrated with the use of ITGB1/CD29 hi ITGB3/CD61 + markers to enrich for mammary stem-like cells and ALDH + to identify luminal progenitor-like cells. Macroautophagy/autophagy appears to be important for maintaining the cancer stem-like traits of both these populations. Interestingly, the regulation of these distinct cancer stem-like cells by autophagy occurs through EGFR-STAT3 and TGFB/TGF-β-SMAD pathways, respectively. These findings indicate that autophagy plays a significant role in cancer stem-like cells, and distinct cancer stem-like cells within a tumor may require different treatment modalities.


  • Identifier: System Number: ETOCvdc_100036544669.0x000001; Journal ISSN: 1554-8627; doi/10.1080/15548627.2016.1213928
  • Publication Date: 2016
  • Physical Description: Electronic
  • Shelfmark(s): 1835.065800
  • UIN: ETOCvdc_100036544669.0x000001

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