Myzus persicaeis a well known aphid pest, which can transport plant viruses to plants of the nightshade/potato family, namely the Solanaceae, and other food crops. Our aim was to explore the effects of imidacloprid combined with synergistic agents (Beichuang and Jiexiaoli) onMyzus persicae. Different concentrations of imidacloprid combined with synergistic agents were used to treatM. persicae. Biological activity ofM. persicaewas analyzed under indoor conditions, and the control efficiency of the admixture was determined through field experiments. The penetration rate of the admixture on tobacco leaf andM. persicaewas analyzed, and the liquid surface tension and contact angle was measured. Imidacloprid combined with Beichuang and Jiexiaoli showed significant synergistic effects with high control efficacy. Beichuang and Jiexiaoli significantly improved the penetration of imidacloprid into the cuticle of tobacco leaves and the insect body wall. The surface tension and contact angles were abated by synergists. The combination of imidacloprid with Beichuang and Jiexiaoli showed a significant synergistic effect, which can be used for decreasing the dosage of imidacloprid and improving its long-term control efficacy.