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Novel, One-Pot, Three-Component, Regioselective Synthesis of Fluorine-Containing Thiazole and Bis-3H-thiazole Derivatives Using Polyvinyl Pyridine as Heterogeneous Catalyst, and Evaluation of Their Antibacterial Activity

Abbasi Shiran, Jafar et al.

Synthetic communications -- Taylor & Francis Group -- Volume: 45 13; (pages 1520-1532) -- 2015

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  • Title:
    Novel, One-Pot, Three-Component, Regioselective Synthesis of Fluorine-Containing Thiazole and Bis-3H-thiazole Derivatives Using Polyvinyl Pyridine as Heterogeneous Catalyst, and Evaluation of Their Antibacterial Activity
  • Author: Abbasi Shiran, Jafar;
    Yahyazadeh, Asieh;
    Mamaghani, Manouchehr;
    Yamin, Bohari M.;
    Albadi, Jalal;
    Shirini, Farhad;
    Rassa, Mehdi
  • Found In: Synthetic communications. Volume 45:Number 13(2015); 20150703; 1520-1532
  • Journal Title: Synthetic communications
  • Subjects: Organic compounds Synthesis; Chemistry, Organic; Synthesis; LCSH: Organic compounds Synthesis; Dewey: 547.205
  • Rights: Licensed
  • Publication Details: Taylor & Francis Group
  • Abstract: Abstract

    A convenient, one-pot, three-component regioselective synthesis of novel 2,2′-(1,4-phenylene)-bis-(3-aryl-2-substituted imino-4-aryl-3H-thiazole) derivatives from 1,4-phenylene diisothiocyanate, aryl amines, and various phenacyl bromide, and also the regioselective synthesis of 3-alkyl-2-(aryl imino)-4-cyclopropyl-5-(2′-fluorophenyl)-thiazole derivatives from alkylisothiocyanate, aryl amines, and 2-bromo-2-(2-fluorophenyl)-1-cyclopropylethanone in the presence of poly-4-vinyl pyridine as heterogenous basic catalyst are described. This efficient method produced the products at room temperature with excellent yields (82–96%). The structures of all products were characterized by spectral and elemental analyses. The antimicrobial activity of the synthesized compounds was evaluated againstSalmonella enterica, Micrococcus luteus, Bacillus subtilis, andPseudomonas aeruginosa.

    GRAPHICAL ABSTRACT

  • Identifier: Journal ISSN: 0039-7911
  • Publication Date: 2015
  • Physical Description: Electronic
  • Shelfmark(s): ELD Digital store
    8586.830000
  • UIN: ETOCvdc_100032675834.0x000001

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