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Epithelial-to-Mesenchymal Transition in Renal Neoplasms

He, Huiying; Magi-Galluzzi, Cristina

Advances in anatomic pathology. Volume 21:Issue 3 (2014); pp 174-180 -- Lippincott Williams & Wilkins

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  • Title:
    Epithelial-to-Mesenchymal Transition in Renal Neoplasms
  • Author: He, Huiying;
    Magi-Galluzzi, Cristina
  • Found In: Advances in anatomic pathology. Volume 21:Issue 3 (2014); pp 174-180
  • Journal Title: Advances in anatomic pathology
  • Subjects: Pathology--Periodicals; renal cell carcinoma--sarcomatoid differentiation--EMT; Dewey: 616.0705
  • Rights: Licensed
  • Publication Details: Lippincott Williams & Wilkins
  • Abstract:

    Epithelial-to-mesenchymal transition (EMT) describes a phenotypical change induced in epithelial cells that lose their cell-cell basement membrane contacts and their structural polarity to become spindle-shaped and morphologically similar to mesenchymal/myofibroblast cell. The abnormal induction of EMT has been demonstrated to contribute to cancer dissemination and progression. Renal cell carcinoma (RCC) with sarcomatoid differentiation (sarcomatoid RCC) represents a good example of EMT both morphologically and immunohistochemically. Early spindle cell changes can at times be identified in RCC and likely represent an early step toward EMT. Herein, we present a review of the current understanding of EMT in renal neoplasms including some known signaling regulation, the association of sarcomatoid differentiation in RCC with aggressive behavior and dismal prognosis, and EMT-related tumor biology in sarcomatoid RCC. A better perception of the EMT may contribute toward an improved understanding of the development of sarcomatoid RCC. In addition, a distinct signature for sarcomatoid RCC may have utility in the differential diagnosis for prognostic stratification as well as in identifying novel genes and pathway targets for therapeutic intervention.

  • Identifier: System Number: ETOCvdc_100030150856.0x000001; Journal ISSN: 1072-4109; doi/10.1097/PAP.0000000000000018
  • Publication Date: 2014
  • Physical Description: Electronic
  • Shelfmark(s): 0698.790000
  • UIN: ETOCvdc_100030150856.0x000001

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