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Iodobenzene-catalyzed synthesis of α,α′-dihydroxy ketones: In situ generation of [bis(trifluoroacetoxy)iodo]benzene

Chen, Chengqun; You, Minghua; Chen, Hong

Synthetic communications -- Taylor & Francis Group -- Volume: 46 1; (pages 73-78) -- 2016

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  • Title:
    Iodobenzene-catalyzed synthesis of α,α′-dihydroxy ketones: In situ generation of [bis(trifluoroacetoxy)iodo]benzene
  • Author: Chen, Chengqun;
    You, Minghua;
    Chen, Hong
  • Found In: Synthetic communications. (2016); 20160102; 73-78
  • Journal Title: Synthetic communications
  • Subjects: Organic compounds Synthesis; Chemistry, Organic; Synthesis; LCSH: Organic compounds Synthesis; Dewey: 547.205
  • Rights: Licensed
  • Publication Details: Taylor & Francis Group
  • Abstract: ABSTRACT

    Exposure of ethynyl carbinols to oxone/(CF3CO)2O in the presence of a catalytic amount of iodobenzene affordedα,α′-dihydroxy ketones in good yield, which are common structural motifs in natural products and biologically active compounds. Compared with traditional methods, this method is more convenient and avoids using stoichiometric amounts of hypervalent iodine reagents.

    GRAPHICAL ABSTRACT

  • Identifier: Journal ISSN: 0039-7911
  • Publication Date: 2016
  • Physical Description: Electronic
  • Shelfmark(s): ELD Digital store
    8586.830000
  • UIN: ETOCvdc_100029885946.0x000001

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