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Antimicrobial and antitumor activities of 1,2,4�triazoles/polypyrrole chitosan core shell nanoparticles

Salahuddin, Nehal et al.

Journal of physical organic chemistry. VOL 30; NUMBER 12, ; 2017, NA -- John Wiley & Sons, Ltd

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  • Title:
    Antimicrobial and antitumor activities of 1,2,4�triazoles/polypyrrole chitosan core shell nanoparticles
  • Author: Salahuddin, Nehal;
    Elbarbary, Ahmed A.;
    Salem, Mohamed L.;
    Elksass, Samar
  • Found In: Journal of physical organic chemistry. VOL 30; NUMBER 12, ; 2017, NA
  • Journal Title: Journal of physical organic chemistry.
  • Subjects: Biotechnology; Chemistry; Pharmaceutical Chemistry; Dewey: 547.1393
  • Publication Details: John Wiley & Sons, Ltd
  • Language: English
  • Abstract: Combination of natural biodegradable polymer with a synthetic polymer offers excellent properties for the support in drug delivery system. For this purpose, biodegradable conductive nanoparticle polypyrrole based on chitosan (PPC) has been prepared via oxidative polymerization of pyrrole in presence of chitosan using FeCl3 as oxidant in acidic medium and used as a carrier for 1,2,4â€?triazoles. The resultant nanoparticles were characterized by Xâ€?ray diffraction, Fourier transform infrared analysis, transmission electron microscopy, scanning electron microscopy, and thermal gravimetric analysis. The results indicate that spherical nanoparticle of average diameter 52 ± 8 nm was successfully prepared. The spherical particles were composed of dark sphere surrounded by grey shell. A circumferential dark ring is observed in the shell after loading 1,2,4â€?triazoles into PPC nanoparticles. The loaded triazoles were released almost linearly against time in a sustained fashion into different pH media. The mechanism of triazoles release was determined using different kinetics equations. The antibacterial activities against the gramâ€?negative and gramâ€?positive bacteria were examined. Furthermore, the antitumor activity of PPC nanoparticles loaded 1,2,4â€?triazoles was also examined against Ehrlich ascites carcinoma cells and breast cancer cell line (MCF7). Polypyrrole chitosan loaded nanoparticles exhibited higher antitumor activity than 1,2,4â€?triazoles.
  • Identifier: System Number: ETOCRN389937287; Journal ISSN: 0894-3230
  • Publication Date: 2017
  • Physical Description: Physical
  • Accrual Information: Monthly
  • Shelfmark(s): 5036.211000
  • UIN: ETOCRN389937287

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