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MAGI-1 expression is decreased in several types of human T-cell leukemia cell lines, including adult T-cell leukemia

Kozakai, T. et al.

International journal of hematology : the official journal of the Japanese Society of Hematology. VOL 107; NUMBER 3, ; 2018, 337-344 -- Springer Science + Business Media

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  • Title:
    MAGI-1 expression is decreased in several types of human T-cell leukemia cell lines, including adult T-cell leukemia
  • Author: Kozakai, T.;
    Takahashi, M.;
    Higuchi, M.;
    Hara, T.;
    Saito, K.;
    Tanaka, Y.;
    Masuko, M.;
    Takizawa, J.;
    Sone, H.;
    Fujii, M.
  • Found In: International journal of hematology : the official journal of the Japanese Society of Hematology. VOL 107; NUMBER 3, ; 2018, 337-344
  • Journal Title: International journal of hematology : the official journal of the Japanese Society of Hematology.
  • Subjects: Medicine; Biotechnology; Pharmaceutical Chemistry; LCC: QC320 QC; Dewey: 616.15
  • Publication Details: Springer Science + Business Media
  • Language: English
  • Abstract: Membrane-associated guanylate kinase with inverted orientation protein 1 (MAGI-1) is a cytoplasmic scaffold protein that interacts with various signaling molecules; it negatively controls the cell growth of various types of cells and positively controls cell–cell interaction. In T cells, MAGI-1 has been shown to inhibit Akt activity through its interaction with PTEN and MEK1. In this study we found that MAGI-1 expression is decreased in multiple (9 out of 15) human T-cell leukemia cell lines, including adult T-cell leukemia (ATL), T-cell acute lymphoblastic leukemia and chronic T-cell lymphocytic leukemia. The overexpression of MAGI-1 protein in a MAGI-1-low ATL cell line reduced cellular growth. While the overexpression of MAGI-1 protein in a MAGI-1-low ATL cell line reduced the Akt and MEK activities, the knockdown of MAGI-1 in a MAGI-1-high ATL cell line augmented the Akt and MEK activities. Collectively, the findings of the present study suggest that the decreased expression of MAGI-1 in human T cells contributes to the development of several types of T-cell leukemia, partly through the stimulation of the Akt and MEK pathways.
  • Identifier: Journal ISSN: 0925-5710
  • Publication Date: 2018
  • Physical Description: Physical
  • Accrual Information: Monthly
  • Shelfmark(s): 4542.280400
  • UIN: ETOCRN387828253

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