skip to main content
Show Results with:

Screening and characterization of cocrystal formation of metaxalone with short-chain dicarboxylic acids induced by solvent-assisted grinding approach

Lin, H. L.; Wu, T. K.; Lin, S. Y.

Thermochimica acta. VOL 575, ; 2014, 313-321 -- Elsevier Science B.V., Amsterdam. Part; (pages 313-321) -- 2014

Online access

  • Title:
    Screening and characterization of cocrystal formation of metaxalone with short-chain dicarboxylic acids induced by solvent-assisted grinding approach
  • Author: Lin, H. L.;
    Wu, T. K.;
    Lin, S. Y.
  • Found In: Thermochimica acta. VOL 575, ; 2014, 313-321
  • Journal Title: Thermochimica acta.
  • Subjects: Biotechnology; Chemistry; Pharmaceutical Chemistry; LCC: QD510; Dewey: 540
  • Publication Details: Elsevier Science B.V., Amsterdam.
  • Language: English
  • Abstract: A solvent-assisted grinding approach was used to investigate the possible cocrystal formation between metaxalone and short-chain dicarboxylic acids (HOOC?(CH2)n?COOH, n=0-3). Differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) microspectroscopy, and powder X-ray diffraction (PXRD) were used to verify the cocrystal formation between metaxalone and each dicarboxylic acid. As a standard reference, a cocrystal was prepared by solvent evaporation method. The cocrystal formation was also quickly estimated by using a one-step simultaneous DSC-FTIR microspectroscopy. The present study indicates that only n=2 of short-chain dicarboxylic acids such as succinic acid, fumaric acid and maleic acid can form a cocrystal with metaxalone through solvent-assisted grinding in a short time. Moreover, this cocrystal formation was easily screened and estimated using a unique DSC-FTIR microspectroscopy.
  • Identifier: Journal ISSN: 0040-6031
  • Publication Date: 2014
  • Physical Description: Electronic
  • Shelfmark(s): 8814.820000
  • UIN: ETOCRN344804760

Searching Remote Databases, Please Wait