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Development of a fast liquid chromatography–tandem mass spectrometry method for the determination of endocrine-disrupting compounds in waters

Carro, M. et al.

Analytical and bioanalytical chemistry. VOL 398; NUMBER 2, ; 2010, 1025-1034 -- Springer Science + Business Media (pages 1025-1034) -- 2010

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  • Title:
    Development of a fast liquid chromatography–tandem mass spectrometry method for the determination of endocrine-disrupting compounds in waters
  • Author: Carro, M.;
    Scapolla, C.;
    Liscio, C.;
    Magi, E.
  • Found In: Analytical and bioanalytical chemistry. VOL 398; NUMBER 2, ; 2010, 1025-1034
  • Journal Title: Analytical and bioanalytical chemistry.
  • Subjects: Biotechnology; Chemistry; Pharmaceutical Chemistry; LCC: QD71; Dewey: 543
  • Publication Details: Springer Science + Business Media
  • Language: English
  • Abstract: A fast liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS-MS) method was developed to study five endocrine-disrupting compounds (4-n-nonylphenol, bisphenol A, estrone, 17β-estradiol and 17α-ethinylestradiol) in water. Different columns were tested; the chromatographic separation of the analytes was optimized on a Pinnacle DB biphenylic column with a water–acetonitrile gradient elution, which allowed the separation of the selected endocrine-disrupting compounds (EDCs) in less than 6 min. Quantitative analysis was performed in selected reaction monitoring (SRM) mode; two transitions were chosen for each compound, using the most abundant for quantitation. Calibration curves using bisphenol A-d 16 as internal standard were drawn, showing good correlation coefficients (0.9993–0.9998). All figures of merit of the method were satisfactory; limits of detection were in the low pg range for all analytes. The method was then applied to the determination of the analytes in real water samples: to this aim, polar organic chemical integrative samplers (POCIS) were deployed in the influent and in the effluent of a drinking water treatment plant in Liguria (Italy). The EDC level was rather low in the influent and negligible in the outlet, reflecting the expected function of the treatment plant.
  • Identifier: Journal ISSN: 1618-2642
  • Publication Date: 2010
  • Physical Description: Electronic
  • Shelfmark(s): 0896.320000
  • UIN: ETOCRN278114039

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