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Contribution of endothelin-1 to the enhanced carotid body chemosensory responses induced by chronic intermittent hypoxia

Rey, S.; Del Rio, R.; Iturriaga, R.

Brain research. VOL 1086; NUMBER 1, ; 2006, 152-159 -- Elsevier Science B.V., Amsterdam. (pages 152-159) -- 2006

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  • Title:
    Contribution of endothelin-1 to the enhanced carotid body chemosensory responses induced by chronic intermittent hypoxia
  • Author: Rey, S.;
    Del Rio, R.;
    Iturriaga, R.
  • Found In: Brain research. VOL 1086; NUMBER 1, ; 2006, 152-159
  • Journal Title: Brain research.
  • Subjects: Life Sciences; LCC: QP376; Dewey: 573.86
  • Publication Details: Elsevier Science B.V., Amsterdam.
  • Language: English
  • Abstract: Chronic intermittent hypoxia (CIH) enhances carotid body (CB) chemosensory responses to acute hypoxia. We tested the hypothesis that endothelin-1 (ET-1), an excitatory modulator of CB chemoreception may contribute to the enhanced CB chemosensory responses in cats exposed to cyclic hypoxic episodes repeated during 8 h for 4 days. Accordingly, we measured the ET-1 immunoreactivity (ET-ir) in the CB and plasma. Using a perfused CB preparation, we studied the effects of exogenous ET-1 and bosentan, a non-selective endothelin receptor type A and B antagonist, on the frequency of chemosensory discharges (Æ’x) during normoxia, mild and severe hypoxia. We found that CIH increased ET-ir in the CB by ∼10-fold leaving ET-1 plasma levels unchanged. Application of ET-1 to control and CIH-treated CBs produced long-lasting dose-dependent increases in Æ’x, although the dose–response curve showed a rightward-shift in the CIH-treated CBs. CIH increased baseline Æ’x and hypoxic chemosensory responses, which were reduced by 50 μM bosentan in CBs from CIH-treated cats. Present results suggest that a local increase of ET-1 in the CB may contribute to the enhanced chemosensory responses induced by CIH predominantly through a vasomotor mechanism.
  • Identifier: Journal ISSN: 0006-8993
  • Publication Date: 2006
  • Physical Description: Electronic
  • Shelfmark(s): 2268.200000
  • UIN: ETOCRN187080433

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