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Morbidity associated with intraportal islet transplantation

Bucher, P. et al.

Transplantation proceedings. VOL 36; NUMBER 4, ; 2004, 1119-1120 -- Elsevier Science B.V., Amsterdam. (pages 1119-1120) -- 2004

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  • Title:
    Morbidity associated with intraportal islet transplantation
  • Author: Bucher, P.;
    Mathe, Z.;
    Bosco, D.;
    Becker, C.;
    Kessler, L.;
    Greget, M.;
    Benhamou, P. Y.;
    Andres, A.;
    Oberholzer, J.;
    Buhler, L.
  • Found In: Transplantation proceedings. VOL 36; NUMBER 4, ; 2004, 1119-1120
  • Journal Title: Transplantation proceedings.
  • Subjects: Medicine; LCC: RD120; Dewey: 617.95
  • Publication Details: Elsevier Science B.V., Amsterdam.
  • Language: English
  • Abstract: IntroductionComplications associated with intraportal islet infusion have been reported. In this study, we analyzed the relationship between occurrence of complications and islet preparation characteristics/infusion technique.MethodsWe reviewed all intraportal islet infusions from 1992 to 2003.ResultsSixteen islet autotransplantations were performed without infusion-related complications. The tissue volume injected was 13 +- 11 mL with basal and peak portal pressures of 13 +- 6 and 21 +- 6 mm Hg. Seventy-seven intraportal islet allotransplantations were performed in 51 patients. Fifteen islet infusions were done by laparotomy during simultaneous islet/kidney transplantation without complication. Among 62 percutaneous transhepatic injections, nine complications (two portal branch thrombosis and seven intra-abdominal hemorrhages) were recorded. Rise in portal pressure was related to tissue volume injected (P P > .05). Complications occurred only after percutaneous islet infusion (P ConclusionsProcedure-related morbidity of intraportal islet infusion is low. Changes in portal pressure are related to volume of tissue injected but do not seem to be associated with the occurrence of complications. Percutaneous infusion is a minimally invasive procedure, but this advantage must be balanced by the higher rate of complications.
  • Identifier: Journal ISSN: 0041-1345
  • Publication Date: 2004
  • Physical Description: Electronic
  • Accrual Information: Quarterly
  • Shelfmark(s): 9025.100000
  • UIN: ETOCRN151051039

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