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Proteinase inhibitors I and II from potatoes specifically block UV-induced activator protein-1 activation through a pathway that is independent of extracellular signal-regulated kinases, c-Jun N-terminal kinases, and P38 kinase

Huang, C. et al.

Proceedings of the National Academy of Sciences of the United States of America. VOL 94; NUMBER 22, ; 1997, 11957-11962 -- NATIONAL ACADEMY OF SCIENCES Part: Part 22; (pages 11957-11962) -- 1997

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  • Title:
    Proteinase inhibitors I and II from potatoes specifically block UV-induced activator protein-1 activation through a pathway that is independent of extracellular signal-regulated kinases, c-Jun N-terminal kinases, and P38 kinase
  • Author: Huang, C.;
    Ma, W.-Y.;
    Ryan, C. A.;
    Dong, Z.
  • Found In: Proceedings of the National Academy of Sciences of the United States of America. VOL 94; NUMBER 22, ; 1997, 11957-11962
  • Journal Title: Proceedings of the National Academy of Sciences of the United States of America.
  • Subjects: Mathematics; LCC: Q11 Q; Dewey: 505 500
  • Publication Details: NATIONAL ACADEMY OF SCIENCES
  • Language: English
  • Abstract: Solar UV irradiation is the causal factor for the increasing incidence of human skin carcinomas. The activation of the transcription factor activator protein-1 (AP-1) has been shown to be responsible for the tumor promoter action of UV light in mammalian cells. We demonstrate that proteinase inhibitor I (Inh I) and II (Inh II) from potato tubers, when applied to mouse epidermal JB6 cells, block UV-induced AP-1 activation. The inhibition appears to be specific for UV-induced signal transduction for AP-1 activation, because these inhibitors did not block UV-induced p53 activation nor did they exhibit any significant influence on epidermal growth factor-induced AP-1 transactivation. Furthermore, the inhibition of UV-induced AP-1 activity occurs through a pathway that is independent of extracellular signal-regulated kinases and c-Jun N-terminal kinases as well as P38 kinases. Considering the important role of AP-1 in tumor promotion, it is possible that blocking UV-induced AP-1 activity by Inh I or Inh II may be functionally linked to irradiation-induced cell transformation.
  • Identifier: Journal ISSN: 0027-8424
  • Publication Date: 1997
  • Physical Description: Physical
  • Shelfmark(s): 6762.000000
  • UIN: ETOCRN034751973

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