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Natural products targeting clinically relevant enzymes / Paula B. Andrade, Patricia Valentao, David M. Pereira.

Paula B. Andrade, author.

Weinheim : Wiley-VCH, 2017.

Online access

  • Title:
    Natural products targeting clinically relevant enzymes / Paula B. Andrade, Patricia Valentao, David M. Pereira.
  • Author: Paula B. Andrade, author.
  • Contributor: Patrícia Valentão author.;
    David Alexandre Micael Pereira author.
  • Subjects: Enzymes -- Effect of drugs on; Natural products -- Therapeutic use; Bioactive compounds;
    Dewey: 612.0151
  • Rights: Terms governing use: Copyright.
    Access restrictions: NON_PRINT_LEGAL_DEPOSIT
  • Publication Details: Weinheim : Wiley-VCH, 2017.
  • Language: English
  • Edition: 1st
  • Description: Contents:

    Lists of Contributors xiii

    1 Natural Products as Enzyme Inhibitors 1
    David M. Pereira, Catarina Andrade, Patricia Valentao, and Paula B. Andrade

    1.1 Why Are Natural Products Good Enzyme Inhibitors? 1

    1.2 Drawbacks of Natural Products 4

    1.3 The Future of Natural Products Drug Discovery 5

    1.3.1 New Sources and New Production Methods 5

    1.3.2 New Strategies for Delivery 9

    1.3.3 New Targets?/Drug Repurposing 12

    1.4 Conclusion 13

    References 13

    2 Molecular Targets of Clinically Relevant Natural Products from Filamentous Marine Cyanobacteria 19
    Lik T.
    Contents: Tan

    2.1 Introduction 19

    2.2 Histone Deacetylase Inhibitors 20

    2.2.1 Largazole 20

    2.2.2 Santacruzamate A 22

    2.3 Proteasome Inhibitors 23

    2.3.1 Carmaphycins 23

    2.4 Protease Enzymes 24

    2.4.1 Serine Protease Inhibitors 24

    2.4.2 Falcipain Inhibitors 27

    2.4.2.1 Gallinamide A 27

    2.4.3 Cathepsin Inhibitors 28

    2.4.4 β?-Secretase 1 (BACE1) Inhibitors 30

    2.4.4.1 Tasiamide B 30

    2.5 Protein Kinase C Modulators 30

    2.5.1 Aplysiatoxins 30

    2.6 Interference of the Actin and Microtubule Filaments 31

    2.6.1 Dolastatins 10/15 31

    2.6.2 Bisebromoamide 32

    2.7 Sec61 Protein Translocation Channel Inhibitors 32

    2.7.1 Apratoxin A 32

    2.8 Prohibitin Inhibitors 34

    2.8.1 Aurilide 34

    2.9 Sodium Channels
    Contents: Modulators 35

    2.10 Conclusions 35

    References 36

    3 Natural Angiotensin Converting Enzyme (ACE) Inhibitors with Antihypertensive Properties 45
    Maria Margalef, Francisca I. Bravo, Anna Arola-Arnal, and Begona Muguerza

    3.1 Introduction 45

    3.2 Mechanisms of Blood Pressure Regulation 46

    3.2.1 Renin–Angiotensin–Aldosterone System 46

    3.3 The Treatment of Hypertension 47

    3.3.1 Angiotensin Converting Enzyme Inhibitors 47

    3.4 Natural Products as Angiotensin Converting Enzyme Inhibitors 50

    3.4.1 Polyphenols 50

    3.4.2 Protein Derived Peptides 55

    3.5 Conclusions 58

    References 58

    4 Phospholipase A2 Inhibitors of Marine Origin 69
    Tania Silva, David M. Pereira, Patricia Valentao, and Paula B.
    Contents: Andrade

    4.1 Relevance of Marine Organisms 69

    4.2 Inflammation 69

    4.2.1 Phospholipase A2 70

    4.3 Marine Molecules as PLA2 Inhibitors 72

    4.3.1 Sponge?]Derived Metabolites 72

    4.3.2 Metabolites from Other Organisms 83

    4.4 Conclusion 86

    References 86

    5 β-Secretase (BACE1) Inhibitors from Natural Products 93
    Wei?-Shuo Fang, Deyang Sun, Shuang Yang, and Na Guo

    5.1Introduction 93

    5.2 Flavonoids 94

    5.2.1 Flavones,
    Contents: Flavonols and Flavone Glycosides 95

    5.2.2 Dihydroflavonoids 96

    5.2.3 Biflavonoids 98

    5.2.4 Chalcones 100

    5.2.5 Isoflavonoids 102

    5.2.6 Catechins 102

    5.2.7 Xanthones 104

    5.3 Chromones 104

    5.4 Phenolic Acids and Tannins 105

    5.4.1 Phenol Acids 105

    5.4.2 Tannins 106

    5.4.3 Simple Phenol Derivatives and Polyphenols 107

    5.5 Stilbenes and Derivatives 110

    5.6 Coumarins 112

    5.7 Benzoquinones and Anthraquinones 114

    5.8 Alkaloids 116

    5.9 Terpenes 118

    5.10 Lignans 120

    5.11 Fatty Acid 121

    5.12 Saccharides,
    Contents: Peptides and Amino Acid Derivatives 121

    5.13 BACE1 Inhibitory Active Extracts of Natural Products 122

    5.14 Bioassays for the Discovery of BACE1 Inhibitors 124

    5.15 Prospective 124

    5.16 Acknowledgements 125

    References 125

    6 Hypoglycaemic Effects of Plants Food Constituents via Inhibition of Carbohydrate-Hydrolysing Enzymes: From Chemistry to Future Applications 135
    Monica R. Loizzo, Marco Bonesi, Seyed M.
    Contents: Nabavi, Eduardo Sobarzo
    ?]Sanchez, Luca Rastrelli, and Rosa Tundis

    6.1 Introduction 135

    6.2 α-Amylase 136

    6.3 α-Glucosidase 137

    6.4 Hypoglycaemic Natural Compounds 137

    6.4.1 Flavonoids 139

    6.4.2 Phenolic Acids 141

    6.4.3 Terpenoids 142

    6.4.4 Alkaloids 147

    6.4.5 Tannins 150

    6.4.5.1 Ellagitannins 150

    6.4.6 Miscellaneous 152

    6.5 Conclusions and Future Perspective 152

    Abbreviations 153

    References 153

    7 Natural Products Targeting Clinically Relevant Enzymes of Eicosanoid Biosynthesis Implicated in Inflammation and Cancer 163
    Gorla V. Reddy, Nagendra S. Yarla, Shobha Ediga, Dinesh K. Tiwari, Naresh Kumar, Sandhya Singh, Vasundhra Bhandari, Anupam Bishayee, Chintalapally V.
    Contents: Rao,
    Contents: and Pallu Reddanna

    7.1 Introduction 163

    7.2 Eicosanoid Biosynthetic Pathways 164

    7.2.1 Phospholipases 165

    7.2.2 Cyclooxygenases 166

    7.2.3 Lipoxygenases 166

    7.2.4 Cytochrome P450 (CYP)?]dependent Monooxygenases 166

    7.3 Eicosanoid Biosynthetic Pathways in Inflammation and Cancer 167

    7.3.1 Role of PLA2s in Inflammation and Cancer 167

    7.3.2 Role of COXs in Inflammation and Cancer 168

    7.3.3 Role of LOXs in Inflammation and Cancer 169

    7.3.4 Role of CYP?]dependent Monooxygenases in Inflammation and Cancer 170

    7.4 Natural Products as Anti-inflammatory Agents 170

    7.4.1 Natural Products from Plant Origin 170

    7.4.1.1 Baicalein 170

    7.4.1.2 Berberine 171

    7.4.1.3 Chebulagic Acid 172

    7.4.1.4 Curcumin 172

    7.4.1.5 Ellagic Acid 173

    7.4.1.6
    Contents: Epigallocatechin?]3?]Gallate 174

    7.4.1.7 Eugenol 174

    7.4.1.8 Fisetin 174

    7.4.1.9 Gallic Acid 175

    7.4.1.10 Genistein <

  • Identifier: ISBN 9783527805938 (ePub ebook) : £100.00; ISBN £110.00; ISBN 9783527805914 (PDF ebook) : £100.00; ISBN 9783527805945 (Mobipocket ebook) : £100.00; BNB GBB7C4358; System number: 018431192
  • Physical Description: 1 online resource.
  • Shelfmark(s): General Reference Collection DRT ELD.DS.176260
  • UIN: BLL01018431192

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