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Multidrug evolutionary strategies to reverse antibiotic resistance

Science, 2016 Jan 1, Vol.351(6268) [Peer Reviewed Journal]

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  • Title:
    Multidrug evolutionary strategies to reverse antibiotic resistance
  • Author: Baym, M ; Stone, Lk ; Kishony, R
  • Found In: Science, 2016 Jan 1, Vol.351(6268) [Peer Reviewed Journal]
  • Subjects: Drug Resistance ; Antibiotics ; Bacteria
  • Language: English
  • Description: Antibiotic resistance threatens to put modern medicine into reverse. But we are not at the end of our options for currently available drugs. Baym et al. review what can be done by using combinations of antibiotics to circumvent bacteria's evolutionary strategies. For instance, resistance to one drug may cause sensitivity to another, the effectiveness of two drugs can be synergized by a resistance mutation, and some negative drug interactions may even be beneficial in selecting against resistance. Although not simple to assess, drug combinations still have something to offer for the development of sorely needed anti-infectives. Science, this issue p. 10.1126/science.aad3292 Antibiotics are among the most important tools in medicine, but their efficacy is threatened by the evolution of resistance. Since the earliest days of antibiotics, resistance has been observed and recognized as a threat; today, many first-generation drugs are all but ineffective. The paradox of antibiotics is that through...
  • Identifier: ISSN: 0036-8075 ; DOI: 10.1126/science.aad3292

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