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GENE THERAPY: A NOVEL APPROACH TO TREATMENT OF THE DEGENERATION OF INTERVERTEBRAL DISCS

Journal of Musculoskeletal Research, 1900, Vol.6(3n04), pp.181-187 [Peer Reviewed Journal]

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  • Title:
    GENE THERAPY: A NOVEL APPROACH TO TREATMENT OF THE DEGENERATION OF INTERVERTEBRAL DISCS
  • Author: Tan, Jiangwei ; Hu, Yougu
  • Found In: Journal of Musculoskeletal Research, 1900, Vol.6(3n04), pp.181-187 [Peer Reviewed Journal]
  • Subjects: Gene Therapy ; Disc Degeneration ; Adenovirus ; Tgf-Β1 ; Gene Expression ; Proteoglycan ; Collagen Type II ; Medicine ; Anatomy & Physiology
  • Language: English
  • Description: The degeneration of intervertebral discs is one of the pathophysiological causes of lowback pain which has been seriously disturbing human health at the present, No clinical approach can provide prophylaxis or treatment for disc degeneration. But people are now thinking about gene transfer for the prevention of disc degeneration to reduce the incidence of back pain. This idea originated from the development of molecular biology; the deep understanding of the physiology and biochemistry of the intervertebral discs, and the growing scope of gene therapy. The increasing publications on gene therapy for disc degeneration have shown us the future of this research field, and revealed possible difficulties in the process of the study. This article focuses on several important aspects of gene therapy for disc degeneration.
  • Identifier: ISSN: 0218-9577 ; E-ISSN: 1793-6497 ; DOI: 10.1142/S0218957702000897

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