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Gametogenesis Eliminates Age-Induced Cellular Damage and Resets Life Span in Yeast

Science, Jun 24, 2011, Vol.332(6037), pp.1554-1557 [Peer Reviewed Journal]

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  • Title:
    Gametogenesis Eliminates Age-Induced Cellular Damage and Resets Life Span in Yeast
  • Author: Ünal, Elçin ; Kinde, Benyam ; Amon, Angelika
  • Found In: Science, Jun 24, 2011, Vol.332(6037), pp.1554-1557 [Peer Reviewed Journal]
  • Subjects: Yeast ; Eukaryotes ; Aging
  • Language: English
  • Description: Aging results in a slow deterioration of biological structures. Even budding yeast undergo replicative aging, with cells dying after producing a limited number of offspring. However, the effects of aging are not transmitted to offspring: The progeny of old and young organisms have similar life spans. Ünal et al. (p. 1554) find that, in budding yeast, life span is reset during sporulation. The life spans of spores derived from young and aged cells are essentially the same. Indeed, initiation of the sporulation program seems to be the trigger required to reset replicative life span. The transcription factor Ndt80 is associated with the rejuvenation effect, and its ectopic expression extended the life span of vegetatively growing cells. Eukaryotic organisms age, yet detrimental age-associated traits are not passed on to progeny. How life span is reset from one generation to the next is not known. We show that in budding yeast resetting of life span occurs during gametogenesis. Gametes (spores) generated by aged cells show the same replicative potential as gametes generated by young cells. Age-associated damage is no longer detectable in mature gametes. Furthermore, transient induction of a transcription factor essential for later stages of gametogenesis extends the replicative life span of aged cells. Our results indicate that gamete formation brings about rejuvenation by eliminating age-induced cellular damage. [PUBLICATION ]
  • Identifier: ISSN: 00368075 ; DOI: 10.1126/science.1204349

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