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The interface between transcription and mechanisms maintaining genome integrity

Trends in Biochemical Sciences, Jun 2010, Vol.35(6), p.333 [Peer Reviewed Journal]

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  • Title:
    The interface between transcription and mechanisms maintaining genome integrity
  • Author: Svejstrup, Jesper
  • Found In: Trends in Biochemical Sciences, Jun 2010, Vol.35(6), p.333 [Peer Reviewed Journal]
  • Subjects: Genomics ; Gene Expression ; Deoxyribonucleic Acid–DNA ; RNA Polymerase ; Eukaryotes
  • Language: English
  • Description: Maintaining genome integrity is crucial for correctly regulated gene expression. Conversely, the process of transcription fundamentally impinges on genome stability, necessitating cellular mechanisms that lessen the genome destabilizing effect of reading genes. This review provides an overview of our present knowledge of how eukaryotic RNA polymerase II transcription affects, and is affected by, other DNA-related processes such as chromatin remodeling, DNA repair, recombination and replication. [PUBLICATION ]
  • Identifier: ISSN: 09680004 ; E-ISSN: 13624326

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