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An Ancient Portal to Proteolysis

Science, Aug 17, 2012, Vol.337(6096), pp.813-814 [Peer Reviewed Journal]

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  • Title:
    An Ancient Portal to Proteolysis
  • Author: Matouschek, Andreas ; Finley, Daniel
  • Found In: Science, Aug 17, 2012, Vol.337(6096), pp.813-814 [Peer Reviewed Journal]
  • Subjects: Biodegradation ; Eukaryotes ; Proteins ; Proteases
  • Language: English
  • Description: Selective protein degradation in eukaryotes is mediated primarily by the ubiquitin-proteasome system, in which the small protein ubiquitin is covalently attached to a target protein to signal its degradation by the 26S proteasome . The ubiquitin-proteasome system may include as many as 1000 distinct gene products, thus constituting one of the broadest regulatory systems in nature. Recent work, including a report by Barthelme and Sauer on page 843 of this issue , has shed light on how this baroque pathway may have evolved and raises some unexpected possibilities for the mechanism by which proteins are delivered to proteasomes for their destruction. [PUBLICATION ]
  • Identifier: ISSN: 00368075 ; E-ISSN: 10959203 ; DOI: 10.1126/science.1227301

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