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ANRIL and ANRASSF1 long noncoding RNAs are upregulated in gastric cancer

Kangarlouei, Roghayeh et al.

Journal of cellular biochemistry. Volume 120:Number 8 (2019, August); pp 12544-12548 -- Wiley Periodicals, Inc

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  • Title:
    ANRIL and ANRASSF1 long noncoding RNAs are upregulated in gastric cancer
  • Author: Kangarlouei, Roghayeh;
    Irani, Shiva;
    Noormohammadi, Zahra;
    Memari, Fereidoon;
    Mirfakhraie, Reza
  • Found In: Journal of cellular biochemistry. Volume 120:Number 8 (2019, August); pp 12544-12548
  • Journal Title: Journal of cellular biochemistry
  • Subjects: Cytochemistry--Periodicals; ANRASSF1--ANRIL--expression--gastric cancer--long noncoding RNAs; Dewey: 572
  • Rights: Licensed
  • Publication Details: Wiley Periodicals, Inc
  • Abstract: Abstract:

    Gastric cancer (GC) is the fifth most frequent cancer and the third‐leading cause of cancer‐related death worldwide. It is a highly heterogeneous disease regarding the morphological and molecular viewpoints. Since it is curable in primary stages, early detection could improve the survival rate. Long noncoding RNAs contribute to a variety of cellular mechanisms, and their dysregulation is reported in various diseases such as cancer. Thus, they have a great potential to be used as diagnostic and prognostic biomarkers and therapeutic targets as well. In the current study, ANRILandANRASSF1expression levels were compared between GC tumors and the adjacent normal tissues collected from 39 Iranian patients using the quantitative real‐time polymerase chain reaction method. Correlation betweenANRILandANRASSF1expression levels and other clinical parameters was also evaluated.ANRILandANRASSF1were significantly overexpressed in GC tumors compared with adjacent tissues (P < 0.0001 andP = 0.001, respectively). No significant correlation betweenANRILandANRASSF1expression levels and demographic information was found. This study suggests thatANRILandANRASSF1may play a critical role in GC progression and can be considered as a potential diagnostic or therapeutics biomarkers.


  • Identifier: System Number: ETOCvdc_100084094704.0x000001; Journal ISSN: 0730-2312
  • Publication Date: 2019
  • Physical Description: Electronic
  • Shelfmark(s): 4955.010000
  • UIN: ETOCvdc_100084094704.0x000001

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